We are excited to announce the release of our latest scientific article: “Drug–device combinations in rare diseases: Challenges and opportunities” published in Drug Discovery Today, co-authored by members of Therapies & Interdisciplinary Scientific Committees.
Why does this matter?
Drug–device combinations (DDCs) offer a groundbreaking approach to treating rare diseases by enhancing drug delivery, improving targeting, and minimizing side effects. However, their development is hindered by complex regulatory frameworks and the absence of specific incentives—unlike orphan drugs.
The publication highlights:
- An overview of the current landscape of DDCs for rare diseases;
- Case studies showcasing their therapeutic potential;
- An analysis of regulatory, ethical, and financial challenges;
- Recommendations for tailored policies to accelerate development.
Read the full article, available open access, here: https://doi.org/10.1016/j.drudis.2025.104343
More IRDiRC publications: https://irdirc.org/activities/irdirc-publications/