IRDiRC has four Scientific Committees:
- Diagnostics Scientific Committee (DSC)
- Interdisciplinary Scientific Committee (ISC)
- Therapies Scientific Committee (TSC)
- Regulatory Scientific Committee (RSC)
Each Scientific Committee is composed of approximately 15 members with balanced expertise and representation from academia, patient organizations, diagnostics, pharmaceutical industry, and regulatory bodies. The Scientific Committees identify and propose actionable projects to advance rare disease research, report on Task Force activities and progress made from a scientific point of view, advise the Consortium Assembly on research priorities and funding gaps, and execute activities in their scientific areas that will bring IRDiRC closer to its goals. Members of the Scientific Committees are nominated for their individual expertise and approved by the Consortium Assembly. The duration of the initial mandate of the Scientific Committees members is 3 years, with the possibility of one renewal. The Chair and the Vice Chair of each Scientific Committee are elected for a period of 3 years that can be renewed once.