The Therapies Scientific Committee (TSC) is establishing a Task Force on Preventive Medicines, where drug activity can either halt or suppress the onset of disease symptoms or the condition itself.
Across different stakeholders, there is a growing consensus that prevention must become a more significant part of health policy and pharmaceutical development programmes. The aim of the Task Force is to create enhanced opportunities for the development of and access to Preventive Medicines at scale for rare diseases. For prevention to be successful there needs to be early and robust diagnosis that can be linked to the administration of a biologically plausible intervention.
The Task Force proposes to map the current pathway(s) and create recommendations that recognise and manage the additional uncertainties of earlier intervention and small population research. New development, approval and reimbursement mechanisms could be implemented to accept the earlier diagnostic paradigm, with the broader use of synthetic data, surrogate marker endpoints and long-term real-world monitoring.
IRDiRC is looking for members to support this Task Force with the below expertise in the following areas (with a demonstrable focus in the prevention space):
- Diagnostic and biomarker
- Surrogate marker endpoints (including qualification and validation)
- Non-clinical models
- Posology methodology
- Drug developer (industry and academia)
- Digital twin, in silico and modelling and simulation
- Registries, natural history studies, real world data
- Regulatory Science (practice and policy makers)
- HTA and payer
The usual time commitment includes monthly 1-hour teleconferences, one face to face workshop (1-1.5 days), regular email correspondence and collaborative working, with the opportunity to co-author peer reviewed article(s).
If you are interested in taking part in this activity, please send a CV, biosketch and letter of motivation clearly describing your expertise in prevention to the Scientific Secretariat scientific.secretariat[at]irdirc.org before the 9th of February 2025.
Please add in the subject of your email the reference for this call Ref: TF-PM.
Only selected candidates will be contacted.