Academy of Finland

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CDNF and CDNF variants- novel therapy for ALS
Development of gene and cell therapy for apeced
Genomic editing for treating hemoglobin diseases
Genomic Profiling of Gynecological Tumors
Hereditary neuropathy and spastic paraplegia: new mechanisms, biomarkers and treatment
LAT1-targeted prodrugs for improved drug delivery to invasive glioma cells
Lessons learned from the embryo to help understand neuroblastoma formation
LMNA-related dilated cardiomyopathy: modelling and molecular targeting of cellular stress in vitro and in vivo
The Epigenetic Reign of Intestinal Homeostasis and Aberrancies therein in Celiac Disease

From genomic rearrangements to more efficient treatment in ovarian cancer
Genetic and neuropathological characterization of neurodedegenerative diseases
Identification of Predictive Biomarkers from Big Data and Their Use in Chemoresponse Monitoring
Innate immune signaling in viral infections: targets influenza and Ebola viruses
Mechanisms of tumor predisposition in colorectal cancer syndromes stratified by mismatch repair status
MED12 in Hematological Malignancies
The Breakdown of immunological self-tolerance in a bullous pemphigoid mouse model and in the elderly population

Beta carbonic anhydrase: a new silver bullet against parasitic diseases
Defects of early differentiation of patient-specific neural progenitors in autism spectrum disorder
Molecular Mechanisms of Thyroid Disorders: from Human Diseases to Mouse Models
Muscular dystrophy : molecular pathophysiology of titin mutations and translational medicine
Nuclear Lamin A in Dilated Cardiomyopathy
The role of polyamine metabolism and NAD+-dependent enzymes, sirtuins and poly(ADP-ribose) polymerases, in diseases characterized with mitochondrial dysfunction.

Clinical and genetic characteristics of early-onset osteoporosis
Maternal and fetal genetic susceptibility to pre-eclampsia
Reprogramming normal cells to tissue-specific cancer by defined oncogenic factors
Role of Novel Neurotrophic factors CDNF and MANF in genetic models of amyotrophic lateral sclerosis
The pathogenesis of childhood acute leukemia
Vasculopathy in hantavirus infections

Correlation between alterations of neural stem cell differentiation and phenotype in fragile X syndrome, a model of neurodevelopmental disorders.
Maintenance and translation of mitochondrial DNA in severe multiorgan disorders of childhood.
Nutrient signaling in mitochondrial diseases: molecular mechanisms and strategies for therapy.
Screening the Drosophila genome for new genes involved in mtDNA maintenance and metabolism.

Identifying New Therapeutic Targets For Hereditary Breast Cancers
“NARPANord” – Pathogenesis of Narcolepsy. Narcolepsy as an autoimmune disease and its association with H1N1 epidemics, H1N1 vaccination and other potential environmental triggers-A collaborative Finnish-Swedish project
Apoptosis-induced microparticles and apoptotic bodies as stimuli to plasmacytoid dendritic cell-mediated autoimmunity vs. Tolerance: regulation by estrogens and androgens in an autoimmune exocrinopathy
Craniosynostosis: identifying the mechanisms and preventing the disease
Individualized and combinatorial therapy of AML
Lipid-protein interactions in the mitochondrial inner membrane at nucleoid contact sites
Modelling of monogenic diabetes through stem cells
Molecular mechanisms of neurodegeneration caused by mitochondrial disfunction
Regulation and signaling networks of different Akt isoforms in glioblastoma
Tissue specificity of mitochondrial DNA maintenance
Translational studies of GRACILE syndrome – a model disorder for revealing disease mechanisms and intervention efficacy in mitochondrial dysfunction

Fanconi Anemia/BRCA Pathway and Novel Predisposing Factors in Hereditary breast cancer
Functional and clinical significance of MED29 and ARPC1A amplification target genes in pancreatic cancer
Identification of genetic factors predisposing to diabetic nephropathy
Identify underlying mechanisms connecting autosomal dominant and recessive mitochondrial disease mutations to tissue specific phenotypes
Idiopathic pulmonary fibrosis (IPF) -Development of therapeutic applications
Mechanisms and consequences of mitochondrial translation defects
Mitochondria, metabolism and disease
Mouse and cellular models expressing the alternative oxidase: tools to understand and compensate mitochondrial dysfunctions
Strategies to modify mitochondrial function in order to delay damage generation, increase healthy lifespan and prevent age-related diseases

Alphavirus-induced oncolysis of glioma in immune competent mice: development of sensitive biokmarkers and their use in immunosuppressive combination therapies
Canine Models Of Human Idiopathic Epilepsy
Complex genetics of idiopathic epilepsies
Fetal and childhood mitochondrial genetics and function-effects of novel genes, antiepileptic drugs and alcohol exposure
Finnish Centre of Excellence in Research on Mitochondrial Disease and Ageing (FinMIT)
Identification of genetic factors predisposing to diabetic nephropathy
Identifying New Therapeutic Targets For Hereditary Breast Cancers
Idiopathic pulmonary fibrosis (IPF) -Development of therapeutic applications
iPS cells as tools to study mitochondral disorders
Microglial dysfunction in progressive myoclonus epilepsy, EPM1
Migraine-epilepsy co-morbidity: Rare variants as a tool for identification of susceptibility genes
Mitochondria, metabolism and disease
Mouse and cellular models expressing the alternative oxidase: tools to understand and compensate mitochondrial dysfunctions
Muscular dystrophy — molecular pathophysiology of titin mutations and translational medicine
Nuclear-mitochondrial interactions in Drosophila models of human disease
Role of Kaposi sarcoma herpesvirus-induced cellular reprogramming in cancer development