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2018
- Development of Targeted Frameshifting Technologies
- Evaluating the Outcome of a Novel Strategy to Stimulate mTORC1 Activity in Two MouseModels of CDKL5 Deficiency Disorder
- Generation of CDKL5 deficiency disorder patient-derived iPSC lines
- High Content Screen to identify drug targets for the neuronal manifestations of CDKL5 deficiency
- Quantitative SRM assays for optimization of CDKL5 protein replacement therapy
- Single-cell Transcriptional Profiling of Mosaic CDKL5 Deficiency Disorder Brain Tissue
- Systems Level Analysis of CDKLS Astrocytes to Identify Novel Markers and Pathways in CDKLS Deficiency Disorder (COD)
- Testing functional and structural connectivity in CDKL5 disorder as novel biomarkers
2017
- CDKL5 Syndrome cortical organoids for drug testing and reversibility potential (website)
- Development of biomarkers for CDKL5 activity (website)
- Identification of CDKL5 direct substrates based on kinase assay linked phosphoproteomics (website)
- Innovative Strategy to Enhance the Efficiency of Gene Therapy for CDKL5 Disorder (website)
- Mechanisms and treatment of paradoxical hyperexcitability in CDKL5 Deficiency Syndrome (website)
- Novel CDKL5 complex partners and kinase substrate candidates (website)
- Rescuing CDKL5 mice phenotype by targeting developmental critical period mechanisms (website)
- Therapeutic drug discovery for CDKL5 deficiency using random shRNA selection (website)
- Therapeutic potential of pregnenolone and its synthetic non-metabolized derivative for CDKL5 disorder (website)
- Understanding CDKL5 Expression Pattern by RNAScope in Developing Mouse and Human Glia (website)