mitOmics: Mitochondrial diseases – Definition of genetic architecture through genome sequencing and transcription analysis(website)
2017
ERA-CVD – ACM-HF: In vitro model for heart cell interactions as a new platform for mechanistic insights and therapeutic approaches in genetic heart failure(website)
ERA-CVD – DETECTIN-HF : Determination of the role of clinical and epigenetic risk markers in dilated cardiomyopathy and heart failure(website)
ERA-CVD – VARIATION: New RNA therapies for the treatment of cardiomyopathies caused by LMNA mutations(website)
MAIV: Investigation of time-dependent axon/muscle contacts and formation of mature neuromuscular end plates between human motor neurons (website)
MAIV: Modelling of ALS by direct reprogramming(website)
MAIV: Phenotypic screening of novel small molecule compounds to enhance direct reprogramming efficiency and prevention of motor neurons from cell death(website)
Neuro2D3 – Standardized systems for modelling late-stage neurological diseases and drug screening in 2D and 3D cultures(website)
2016
CHROMATIN-Net: Dissecting the molecular mechanisms of cognitive disorders with mutations in the SWI/SNF complex(website)
CHROMATIN-Net: Establishing human disease specific cortical neurons(website)
CHROMATIN-Net: Functional and phenotypical interaction of cohesin with SWI/SNF-associated disease(website)
CHROMATIN-Net: Intellectual disability (ID) and syndromic entities associated with mutations in the SWI/SNF complex(website)
CHROMATIN-Net: Network on cognitive impairment disorders with defective chromatin (coordination)(website)
CHROMATIN-Net: The nucleosome landscape of Coffin-Siris and Nicolaides-Baraitser syndrome patients with mutations in the SWI/SNF complex(website)
CHROMATIN-Net: Whole Genome Sequencing and Analysis(website)
CMT-NET : Biomarkers, validation of selected outcome measures (CMTNSmod)(website)
CMT-NET : Exome sequencing of extreme phenotypes to identify genetic modifiers in CMT1A(website)
CMT-NET : In vitro: Forward and reverse signaling using barcode sensors in a co-culture model system of CMT1A(website)
CMT-NET : Inflammation as risk factor and therapeutic option(website)
CMT-NET : Lipidtherapy in a transgenic rat model of CMT1A(website)
CMT-NET : Natural history and risk factors during development study in adult CMT patients(website)
CMT-NET : Pathomechanisms of CMT: Relevance for human nerve pathology(website)
CMT-NET : Pregnancy assessment in Charcot-Marie-Tooth (CMT) neuropathy(website)
CMT-NET : Skin biopsies as a tool to identify risk factors from CMT1A patients(website)
CMT-NET : The role of known risk factors regarding neuronal vulnerability using transgenesis in the chick as a model system(website)
CMT-NET : The role of known risk factors with regard to trophic support of axons in Charcot-Marie-Tooth disease using adult Drosophila as a model system(website)
CMT-NET: Network for Research on Charcot-Marie-Tooth disease (coordination)(website)
Costs and financing of patient care in centres for rare diseases in Germany(website)
DYSTRACT: Defining motor system endophenotypes in dystonia using a multimodal neurophysiology and structural imaging approach(website)
DYSTRACT: Elucidation of novel genetic causes and modifiers for dystonia(website)
DYSTRACT: Generation of novel DYT1, DYT6 and DYT12 mouse and rat models of dystonia(website)
DYSTRACT: Genetic fingerprints of oscillatory network activity in dystonia(website)
DYSTRACT: IT platform for the Dystonia Translational Research and Therapy Consortium(website)
DYSTRACT: Modeling dystonia in an endogenous human cellular system: Platform and characterization of iPS derived neurons from patients with monogenic isolated dystonia(website)
DYSTRACT: Musician’s Dystonia as a model for the nature-nurture debate: Classification of endogenous and exogenous trigger factors in musicians dystonia(website)
DYSTRACT: Network on research and management of rare dystonia (coordination)(website)
DYSTRACT: System physiology of dystonia development in rodent models of DYT1 and DYT12(website)
ERA-NET NEURON (DeCipher): Deciphering hyperexcitable networks associated with neurodevelopmental lesions(website)
ERA-NET NEURON (ImprovVision): Stem cells and mechanisms contributing to human cortical malformations(website)
ERA-NET NEURON (ImprovVision): Understanding and reprogramming developmental visual disorders: from anophthalmia to cortical impairments(website)
ERA-NET NEURON (MicroKin): Deciphering the multifaceted pathways underlying MCPH pathogenesis in the mouse and human(website)
ERA-NET TRANSCAN: ARREST – Approaching recurrence and resistance mechanisms in esophagogastric adenocarcinomas from the prospective MEMORI trial -partner DE(website)
ERA-NET TRANSCAN: ARREST – Inter- and intratumoral heterogeneity in adenocarcinoma of the oesophagogastral transition -partner DE(website)
ERA-NET TRANSCAN: DRAMA – Defeating Recurrence and resistance in AML: Multigenomic Approaches to analyse heterogeneity -partner DE(website)
ERA-NET TRANSCAN: FIRE-CLL – Fighting resistance in CLL -partner DE(website)
ERA-NET TRANSCAN: FIRE-CLL – Fighting resistance in CLL -partner DE(website)
ERA-NET TRANSCAN: GCH-CLL – Genetic and cellular intratumor heterogeneity as predictor of chronic lymphocytic leukemia outcome and treatment resistance -partner DE(website)
ERA-NET TRANSCAN: ONTHETRRAC – Analysis of intratumoral molecular heterogeneity (ITH) in neuroblastoma in vivo -partner DE(website)
ERA-NET TRANSCAN: TORPEDO – Targeting Of Resistance in PEDiatric Oncology (coordination)(website)
GeNeRARe: Analysis of the physiopathologic link between constitutional RAS pathway activation and epidermal findings in Costello syndrome(website)
GeNeRARe: German Network for RASopathies (coordination)(website)
GeNeRARe: Mutation spectrum, genotype phenotype correlation and natural history study of RASopathies: consequences for diagnostics and management(website)
GeNeRARe: Neurobiology and neurocognitive function in mouse models of RASpathies(website)
GeNeRARe: The role of oncogene-induced senescence as a tumor suppressive mechanism and as a potential premature aging trigger in Costello syndrome(website)
JPND – CicProt: Protection of synaptic circuits by BDNF/TrkB and arc signalling pathways in mouse models of Alzheimer’s dementia (AD) and Huntington’s disease (HD)(website)
JPND – ModelPolyQ: Further developed models for polyglutamine diseases Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7(website)
JPND – SYNACTION: Analysis of the pathophysiological role of alpha-synuclein aggregation, transport and neuroinflammation in neurodegeneration(website)
MAGEA1-TCR : MAGE-A1 TCR gene therapy of Multiple Myeloma as an example(website)
NCL2TREAT: Clinical diagnostics of neuronal lysosomal storage diseases and quantification of lysosomal enzymes by mass spectrometry(website)
NCL2TREAT: Development of clinical outcome measures in neuronal ceroid lipofuscinoses – new tools for evaluation of experimental therapies(website)
NCL2TREAT: Network for neuronal ceroid lipofuscinoses (coordination)(website)
NCL2TREAT: Pathogenetic mechanisms in CLN6(website)
NCL2TREAT: Towards a therapeutic correction of autophagic flux in an NCL model by preclinical enzyme replacement therapy using recombinant cathepsin-D(website)
NCL2TREAT: Transcriptional modulation of CLN3 deficiency(website)
NEOCYST: Development of standard of care guidelines for cystic kidney disease(website)
NEOCYST: Molecular biology in cystic nephropathies(website)
NEOCYST: Molecular genetics in cystic nephropathies(website)
NEOCYST: Network of Early Onset Cystic Kidney Disease (coordination)(website)
NEOCYST: Urinomics – Identification of biomarkers for cystic kidney diseases(website)
STOP-FSGS: Effect of glucocorticoids in FSGS(website)
STOP-FSGS: Pathogenic mechanism of FSGS and attenuation by pharmaceuticals in zebrafish(website)
STOP-FSGS: Pathogenic role of mTOR signalling in FSGS(website)
STOP-FSGS: Speed Translation-Oriented Progress to diagnose and treat focal segmental glomerulosclerosis (FSGS) – coordination(website)
STOP-FSGS: The tryptophan-kynurenine pathway in podocytes and parietal cells as potential cause for metabolic FSGS(website)
TurbiCAR : Development of an immunomonitoring program for the clinical study(website)
TurbiCAR : Preclinical development and coordination of clinical trials(website)
TurbiCAR : Production of the anti-CD19 target module(website)
2015
AID-Net: Characterisation of ROS-dependent signalling in autoinflammatory processes(website)
AID-Net: Network for Autoinflammatory Disorders in Children and Adolescents (coordination)(website)
AID-Net: Next generation sequencing and bioinformatic strategies(website)
AID-Net: Regulation of interleukin-1ß-synthesis by inflammatory caspases and new IkB proteins(website)
AID-Net: Secretion pathway of immunomodulatory Annexin-1 protein(website)
AID-Net: The role of membrane-pore-forming oligomers in unconventional secretion(website)
AID-Net: The role of proinflammatory s100 proteins in autoinflammatory syndrome(website)
ASD-NET: Analysis of current disease-related costs and models of efficient care for autism spectrum disorders(website)
ASD-NET: Autism spectrum disorder throughout the lifespan – More effective care through valid diagnoses and a better understanding of etiology(website)
Chromatin-Net: Network on cognitive impairmentdisorders with defective chromatin dynamics (CMT-NET)
DYSTRACT: Network on research and management of rare dystonia (DYSTRACT)
ERA-NET NEURON (µNeuroINF): The Role of the Gut Microbiome on Neuroinflammation and Neurodevelopmental Disorders(website)
ERA-NET NEURON (NEUINF): Master regulators of neuroinflammation in parasitic brain infections(website)
ERA-NET NEURON (NEURO-IFN): Investigation of the neuroinflammatory basis of human type I interferonopathies using Aicardi-Goutiéres Syndrome (AGS)(website)
GeNeRARe: German Network for RASopathies(GeNeRARe)
GlioPATH: Comparison of metabolic and signalling pathways in IDH mutant and wild type gliomas(website)
ICON: Analysis of uveitism manifestation and outcome(website)
ICON: Biosample collection and biomarker analysis(website)
ICON: Inception cohort of newly diagnosed patients with juvenile idiopathic arthritis – Multicentre, prospective, controlled observational study(website)
IRMA-4-ALL : Evaluation of the diagnostic quality of the test for measuring the individual therapy response of acute lymphoblastic leukemias(website)
IRMA-4-ALL : Microfluidic integration of the laboratory processes of the test into a centrifugal test carrier(website)
IRMA-4-ALL : Rich client software to support the design of mediator probes for minimal residual disease analysis(website)
IRMA-4-ALL : Transfer of residual cell load quantification to mediator probe PCR and optimization in multiplex approach(website)
JPND – CeBioN: Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis – Partner DE(website)
JPND – CrossSeeds: Mechanisms of pathogenic protein cross-seeding in neurodegenerative disorders (coordination)(website)
JPND – NeuroGeM: Identification of genes that modulate the severity of neurodegenerative diseases – Partner DE(website)
JPND – PrPC&PDK1: PrPC&PDK1: The PrPC / PDK1 / TACE signaling axis at the cross-road of several aggregate-prone protein-associated neurodegenerative diseases – Partner DE(website)
NCL2TREAT: Network for neuronal ceroid lipofuscinoses (NCL2TREAT)
NEOCYST: Network of Early Onset Cystic Kidney Disease (NEOCYST)
Network for imprinting diseases: clinical spectrum and pathogenic mechanisms (coordination)(website)
Network for imprinting diseases: Genetic and epigenetic analysis of patients with imprinting defects(website)
Network for imprinting diseases: Genetic and epigenetic analysis of Silver-Russell syndrome(website)
Network for imprinting diseases: Interaction of imprinted chromosomal domains(website)
Network for imprinting diseases: Multilocus imprint mistakes, TNDM and iPS cells for imprinting diseases(website)
Network for imprinting diseases: Upd(14) syndromes(website)
PID- Net: Development of stem cell gene therapies for patients with PID and colitis(website)
PID- Net: German Network on Primary Immunodeficiency Diseases (coordination)(website)
PID- Net: Phenotypic characterization of mutated procaspase-1 variants in autoinflammation(website)
PID- Net: Reprogramming platform and induced pluripotent disease models for the development of novel therapeutics for PID(website)
PID-Net: Genetic and immunological variability in patients with lymphoproliferation and autoimmunity (ALPS)(website)
PID-Net: Genetics of human (severe) combined immunodeficiency (S)CID(website)
PID-NET: Primary immunodeficiencies predisposing to severe bacterial infections(website)
STOP-FSGS: Speed Translation-Oriented Progress to diagnose and treat focal segmental glomerulosclerosis (FSGS) (STOP-FSGS)
SUPR-G: Systems biology of unfolded protein response in gliomas(website)
2014
mitOmics: Bioinformatic and statistical analysis of genomic data from patients with mitochondrial diseases to identify causal mutations and pathways(website)
mitOmics: Identification of causal disease genes and signalling pathways through systematic and personalised genetic interaction mapping(website)
RHAPSODY – Research to Assess Policies and Strategies for Dementia in the Young (website)
Surviving ARDS: Influence of Quality of Care and Individual Patient Characteristics on Quality of Life/ Return to Work in Survivors of the Acute Respiratory Distress Syndrome (ARDS): Prospective, Observational, Multi-centre Cohort Study (DACAPO) (website)
2012
Genetic modification of the cystic fibrosis transmembrane regulator gene in vitro and in vivo in a mouse model for long-term physiological correction (GALENUS)
German Network for Motor Neuron Diseases (MND-NET)
Genetic modification of the cystic fibrosis transmembrane regulator gene in vitro and in vivo in a mouse model for long-term physiological correction (GALENUS)
German Network for Motor Neuron Diseases (MND-NET)
German Network of Neurological and Ophthalmological Ion Channel Disorders (IonNeurONet)
