Canadian Institutes for Health Research (CIHR), Canada

2016

  • A Realist Synthesis of Housing First Programs: What Works, for Whom, Under What Circumstances in the Community Functioning of Formerly Homeless Adults
  • Defining the role of schwann cell precursors in neural repair.
  • Identification of GBM genetic wiring vulnerabilities.
  • Investigation of premature-aging like phenotypes in ATRX mutant mice
  • Life course-adjusted associations between intrauterine environment and DNA methylation in young adult women of a Jerusalem Perinatal Study sub-cohort.
  • Molecular detection of known and novel cancer predisposition genes
  • OSMR Signalling in Glioblastoma Pathogenesis
  • Personalizing Inhaler Therapy For Men and Women With Chronic Obstructive Pulmonary Disease (COPD)
  • Unraveling the Genetic Architecture of Specific Language Impairment

2015

  • A collaborative filtering based approach to biomedical knowledge discovery
  • A longitudinal study of DNA methylation in women with Anorexia Nervosa: Roles of disorder chronicity, nutritional status and weight restoration
  • A personalized allele-specific gene silencing approach for maximal therapeutic coverage of the Huntington disease population
  • Accelerating vascularization and blood perfusion for cell transplantation and myocardial regeneration
  • Acceleration of Tooth Movement in Bisphosphonate Burdened Alveolar Bone
  • Activation of SREBP2 activity in the absence of calreticulin
  • Adaptation of Bacterial Pathogens
  • Aging effects on components of locomotion, and the impact of increased regular physical activity beginning in late adulthood
  • Anaerobic eukaryotic microbes and the human microbiome: a genomic and metagenomic study
  • Apolipoprotein A-I and apolipoprotein E4 in cerebrovascular health and Alzheimer’s disease pathogenesis
  • Aripiprazole Long Acting Injectable (ALAI), its potential enhancing effect on memory and associated neural structures: A longitudinal brain imaging study in first-episode psychosis
  • Ascending aortic dilation in patients with bicuspid aortic valve disease is marked by accelerated vascular smooth muscle cell aging.
  • Assessing the effectiveness of an online educational intervention to promote skin self-examination among melanoma survivors: A randomized controlled trial
  • Atomic resolution pharmacology of anti-epileptic drugs
  • Behavioural Experiments for Intolerance of Uncertainty: A Single-Component Treatment for Generalized Anxiety Disorder
  • Better Prediction and Decision Support Tools to Improve Care and Outcomes for Patients with Acute Kidney Injury (AKI)
  • Bioinformatic and functional approaches to cancer pharmacogenomics
  • Biomarker Discovery for Stress Related Diseases Using Nuclear Magnetic Resonance Spectroscopy
  • Bridging discovery to clinic: from biomarkers to therapeutic developments in ovarian cancer
  • Canada Research Chair in Molecular Genetics
  • Canada Research Chair in Molecular Hemostasis
  • Canada Research Chair Tier 1
  • Canada Research Chair Tier 2
  • Canadian Glycomics Network (GlycoNet)
  • Cell size specification in normal and malignant populations
  • Central control of osmoregulation in health and disease
  • Characterization of a Novel Bi-genic Mouse Model of Parkinsonism and Dementia with Lewy Bodies
  • Characterizing mechanism of inhibition of Cathepsin K by novel exosite inhibitors
  • Characterizing the role and regulation of the mammalian tumour suppressor gene Fat4 on metabolism, mitochondrial complex activity and stability
  • Close encounters of a Natural Killer kind: Understanding how NK cells protect against HIV infection.
  • Cocooning Therapeutic Cells
  • Cognitive Behavior Therapy for Anxious and Depressed Youth: Improving Outcomes through Mobile Technology
  • Cognitive training in patients with Parkinson’s disease and healthy controls
  • Combining Genomics and Phenomics to identify genes associated with human sensory disorders
  • Common Pathogenic Pathways and Therapeutics for SMA and ALS motoneuron diseases
  • Community, research and public partnerships: A multimedia photo essay exhibit exploring the role of place in shaping the life chances and health outcomes of young people who are living with or at risk of HIV in Vancouver
  • Computation and theory to predict structures and mechanisms for protein misfolding in amyotrophic lateral sclerosis
  • Consequences of Excessive Exercise for Cardiac Arrythmogenesis: What is the Role of Acute and Chronic Inflammation?
  • Copy number variations (CNVs) and colorectal cancer
  • Dclk1+ tuft cells as a cellular origin for inflammation-associated cancer in the gut
  • Deciphering the functional role of Viral protein R (Vpr) during HIV infection
  • Deciphering the metabolic signatures of the metabolic syndrome (MetS) in young children
  • Delivery of CD109-based peptides to antagonize TGF-beta in a murine model of wound healing
  • Des institutions et des femmes : Évolution du nursing psychiatrique au Québec, 1912-1974
  • Determinants of Smoking Cessation Success in the Mass Distribution Paradigm of Nicotine Replacement Therapy
  • Developing a Science of Global Health Strategy
  • Developing an optogenetically-inspired deep brain stimulation protocol to normalize synaptic transmission and abolish pathological behaviour in a SAPAP3 knock-out model of obsessive-compulsive disorder
  • Developing evidence for more effective handrail design to prevent falls and inform changes in the Canada Building Code
  • Development of Genomic and Bioinformatic Tools and Methodologies to Identify Potential Drug Targets for Aortic Stenosis Therapeutics
  • Developmental neurogenetics of schizophrenia: Connecting genetic risk profile scores with hippocampal structure and functioning across the lifespan
  • Développement, optimisation et multiplexage d’un oligonucléotide synthétique permettant l’amplification d’ADN et l’hybridation sur support solide en une seule étape. PDP PhaseI
  • Differences in genetic and diet-induced obesity modulate susceptibility to enteric infection
  • Discovering Spatial Epigenetics
  • Discovery of Novel Resistance Mechanisms against Regulatory T-cells in Tumour Microenvironment
  • Discovery of Novel Therapeutic Targets in Osteosarcoma
  • Dissection of the molecular mechanisms controlling the establishment of neuronal circuitry during development
  • Dynamics of cell-to-cell mediated HIV-1 spread in the lymph node
  • Economic evaluation of a point-of-care transfusion algorithm in cardiac surgery
  • Effect of the gut microbiota and their generated metabolites on HIV-1 biology in CD4+ T cells
  • Effectiveness of interventions for implementation of thromboprophylaxis in hospitalized patients at risk for venous thromboembolism: An updated systematic review and metaanalysis
  • Effects of Housing First on employment and income of homeless individuals: results of a randomized trial
  • Effects of shear stress on atherosclerotic plaque regression
  • Effet de l’âge des culots globulaires transfusés sur le pronostic neurologique suivant un traumatisme craniocérébral (Étude ABLE-tbi)
  • Efficacy and Mechanism of Action of Novel Nucleoside Analogues Against Solid Tumours
  • Elucidating the cause of multiple system atrophy in a Korean cohort
  • Elucidating the Gene-Environment Interactions that drive Autoimmune Disease among South Asian Canadians – The GEMINI Program.
  • Elucidation of regulatory mechanisms modulating STAT3 expression during cancer-induced muscle atrophy
  • Epigenetic and Transcriptomic Disturbances in HIV-Associated COPD
  • Epigenetic Regulation of Muscle Regeneration in Health and Disease
  • Epigenetic Regulation of the Adenovirus Genome
  • Establishing donor-specific transplantation tolerance by harnessing DN regulatory T cells
  • Exome sequencing of patients with Weaver-like features links another cancer gene, EED, to overgrowth syndromes.
  • Exploring Gene/Environment Interaction in the Diabetic Embryopathy Femoral Facial Syndrome
  • Extending circulation time of protein therapeutics by capping glycan structures with 7F-Sialic acids
  • Factors regulating establishment and maintenance of HIV provirus latency
  • Family-based obesity prevention: Identifying effective strategies through epidemiologic research and intervention trials
  • Functional and genomic clonal analysis of human glioblastoma
  • Functional characterization of new regulators of the innate antiviral immunity to develop broad-spectrum antiviral therapies
  • Gata3 and the transciptional control of nephric duct morphogenesis
  • Gene Environment Team on Brown/beige Adipose Tissue (GET_BAT)
  • Genetic and genomic analysis of bacterial cell morphogenesis
  • Genetics of Obesity
  • Gfi1, a new regulator of the DNA Damage Response Pathway in T lymphocytes and T cell Leukemia
  • How a Novel Innate Immune Regulatory Factor Affects Liver Cholesterol and Triglyceride Homeostasis
  • Human Cancer Stem Cell Biology
  • Identification and evaluation of novel therapeutics for myotubular myopathy
  • Identification of new microRNA biomarkers and candidate target genes in primitive CML cells using global comparative RNA analyses
  • Identification of Putative Diagnostic Biomarkers for Breast Cancer through Kinome Analysis
  • Identifying and Planning Research Opportunities in Pediatric Antimicrobial Stewardship: A National Collaboration
  • Identifying High Risk Subsets of Spinal Surgery Patients: Poor Post-Surgical Outcomes and Long-term Opioid Analgesic Use.
  • Immunologial memory of innate lymphocytes and allergic lung inflammation
  • Immunotherapy of familial prion diseases
  • Impact d’un programme d’entraînement sur les déterminants de la consommation d’oxygène maximale chez les patients obèses sévères à 3 et à 6 mois suivant soit une dérivation biliopancréatique avec commutation duodénale ou une gastrectomie pariétale
  • Impact of VEPH1 on cancer associated signaling pathways in the promotion of ovarian cancer
  • Impact of VEPH1 on cancer associated signaling pathways in the promotion of ovarian cancer
  • Implementation and Commercialization of a Novel DNA Methylation-Based Diagnostic Tool
  • Implementation and ethical dimensions of scaling up HIV treatment as prevention (TasP)
  • Importance of tissue-resident memory (Trm) CD8 T cells in controlling SIV infection in mucosal sites of viral entry
  • Improving Depression Screening by Reducing Bias in Accuracy Estimates: An Independent Patient Data Meta-Analysis of the Edinburgh Postnatal Depression Scale (EPDS)
  • Improving hematologic cancer survivors’ health through physical activity: Translating intentions into exercise
  • Incorporating patient preferences into health outcome assessment and economic evaluation for breast cancer: The BREAST-Q Utility Index
  • Innovative chemogenomic tools to improve outcome in acute myeloid leukemia
  • Integrated Genomic and Epigenomic Analysis of Regulatory Elements in Glioblastoma
  • Interpreting genomic data through the study of methylome in Autism Spectrum Disorder
  • Investigating a tumor suppressor role for Parkinson’s susceptibility gene LRRK2 in lung cancer
  • Investigating the Pathophysiology and Treatment of Parkinson’s Disease using 3D Cell Co-Cultures
  • Investigating the role of Staphylococcus aureus IsdB protein in the mechanism for heme-uptake from human hemoglobin.
  • Investigating the use of Smac mimetic compounds combined with innate immune stimuli to induce rhabdomyosarcoma cell death
  • Investigation of premature-aging like phenotypes in ATRX mutant mice
  • Investigation of the sequential development of integrase strand transfer inhibitor resistance mutations in HIV.
  • Investigations of low energy electron damage to DNA: application to Chemoradiation therapy.
  • Linking gene expression to neuronal behaviour in normal and disordered brains through large-scale meta-analysis
  • Lipid metabolism, insulin secretion and energy homeostasis
  • Long QT Syndrome in Northern British Columbia: Predicting Risk for sudden death
  • Maintenance of Polycomb Group protein mediated repression through mitosis.
  • Mechanisms and Risk Stratification for Treatment of Acute Myeloid Leukemia in Children with Down syndrome
  • Mechanisms governing Hepatitis C virus genome stability and viral RNA accumulation
  • Mechanisms of HDL induced signaling in vascular cells and role in protection against coronary artery atherosclerosis.
  • Mesures optiques des processus de plasticité synaptique
  • Misutilization of laboratory tests: pathways to correction
  • Mitochondrial origins of pathological angiogenesis in Age-Related Macular Degeneration
  • Modelling mechanisms of resistance and predictive biomarker discovery against targeted therapy using human primary non-small cell lung cancer xenografts.
  • Modulation of the DNA damage repair (DDR) response in the treatment of brain tumours
  • Modulators of epigenomic processes – a novel approach to cancer therapy
  • Molecular analysis of Herpes simplex virus type I egress
  • Molecular and Genomic Pathology
  • Molecular Brake Mechanisms That Regulate Brain Plasticity and Disease
  • Molecular Determinants of the Li-Fraumeni Syndrome
  • Mutations in a long non-coding RNA cause Myoclonus Dystonia
  • Neurovasculature and hippocampal integrity in early psychosis
  • New mechanisms of podocyte injury in diabetic nephropathy
  • Novel Regulators of Mitochondrial Dynamics
  • Novel therapeutic targets for CCNE1-amplified high-grade serous ovarian carcinomas
  • Novel Therapies for Cystinosis
  • Optically-Guided Biopsy for Improved Diagnosis of Peripheral Pulmonary Nodules
  • Optogenetic Activation Of Hypothalamic Dopamine A11 Neurons Rescues Cataplexy In Narcoleptic Mice
  • OSMR Signalling in Glioblastoma Pathogenesis
  • P2 purinoceptors in the spinal dorsal horn
  • Pannexin-1 channels as therapeutic targets in post-stroke neuroinflammation
  • PARTNERS – Patient Assisted Research Transforming National Effectiveness in Rare Diseases. Creating Pathways Toward Improved Care Delivery, Outcomes and Reduced Burden.
  • Pathobiology of renal dysplasia: a functional role for stromally expressed beta-catenin
  • Peroxisomes in Health and Disease
  • Personalized medicine in the treatment of epilepsy
  • Pharmacogenetics of Antipsychotic Treatment Response in Schizophrenia
  • Pharmacological suppression of cerebral cavernous malformations
  • PKCs as molecular memory traces
  • Platelets and their microparticles: versatile players of inflammation
  • POLR3-related leukodystrophy: From bench to bedside
  • Potential mechanism for ribbon repair after noise induced synaptic damage in the cochlea
  • Probing and Characterizing Resistance to Integrase Inhibitors Using Simian Immunodeficiency Virus 239
  • Promoting Appropriate Body Weight and Optimal Dietary Intake to Pregnant and Postpartum Women in the Context of Community-Based Organizations in Alberta
  • Quantitative Magnetic Resonance Imaging of Brain Structure and Function
  • Quantitative MR Imaging of Vascular Contributions to Aging, Cognitive Decline and Stroke
  • Recombinant hydrolases as anti-biofilm therapies for Aspergillus infections
  • Regenerative Cardiovascular Medicine
  • Regulation of Myogenin by acetyltransferase p300 during myogenic differentiation
  • Repurposing biomolecules for the treatment of epidermolysis bullosa
  • Respiratory mucosal immune responses to environmental exposures relevant in airway health and disease.
  • Rôle de CREB et de ses gènes cibles dans la mémorisation d’une tâche motrice
  • Role of autophagy in Helicobacter pylori infection and disease
  • Role of eurkaryotic elongation factor-2 kinase (eEF2K) in Alzheimer’s disease and relevance for novel therapies.
  • Role of heme oxygenase system in cardiac regeneration and repair in obese Zucker fatty rats
  • Role of oncogenic transcription factors in T-cell acute lymphoblastic leukemia
  • Role of PVRL4 (Nectin-4) receptor in measles virus infections and oncolytic therapy
  • Role of SIX family transcription factors in proliferation and tissue regeneration.
  • Role of small regulatory RNAs expressed by the intracellular pathogen Legionella pneumophila.
  • Ryanodine receptor mutations in stress-induced arrhythmia: correlating molecular structure with disease phenotype
  • Sensori-motor integration in trigeminal circuits of the masticatory central pattern generator
  • Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older adults
  • Slit-Robo Signalling in Atherogenesis
  • Social identity, depression, and the role of the oxytocin receptor gene
  • Strengthening Global Systems to Protect Children: A multi-national analysis of HIV risk and violence against children
  • Stromal influence on epithelial outgrowth and heterogeneity in breast cancer
  • Structural and functional studies at the HIV-1 viral infectivity factor-APOBEC3 axis
  • Structural and functional studies of rhomboid protease PARL (Presenillin-Associated Rhomboid-Like) in Parkinson’s disease
  • Structure-based Antibiotic Discovery on the Bacterial Membrane
  • System Immunobiology of S. aureus pathobiosis: Role of the AhR Gene Program
  • T cell costimulatory signalling in disease progression of angioimmunoblastic T cell lymphoma
  • Targeted intrapulmonary delivery of antiviral and immunomodulatory therapeutics to alleviate severe experimental H7N9 influenza-induced pneumonia
  • Targeting Cancer Drug Resistance: Bioflavonoid-Stimulated Glutathione Efflux by Multidrug Resistance Protein 1
  • Targeting Cell Death Signaling Pathways in the Heart
  • Targeting Colorectal Cancer stem cells self-renewal through EZH2 and PRMT5.
  • Targeting ETS Factor ERG as a Novel Therapeutic for the Treatment of Prostate Cancer
  • Targeting Invadopodia as an Anti-Metastatic Therapy in Breast and Prostate Cancer.
  • Targeting TAZ and YAP: a new approach to anti-fibrotic therapy in the kidney
  • Targeting the tumour cell stress response in high-risk childhood cancers
  • Telomere Length, Stress, and Social Support in Survivors of Paediatric Cancer and their Parents
  • The application of next-generation sequencing technology in identifying the genetic origins of unclassified familial disorders.
  • The development of dysregulation from 3 months to 6 years of age: The interplay of plasticity genes, pre- and postnatal exposure, and early mother-child interaction
  • The Influence of Genetic Risk Factors and Early Life Stress on Myelin Integrity Changes in Depression and Prediction of Treatment Response
  • The regenerative effects of the trophic cytokines granulocyte macrophage-colony stimulating factor and erythropoietin in murine model of Parkinson’s disease.
  • The RGS2-eIF2B binding domain (RGS2eb) as a novel inhibitor of pathological cardiac hypertrophy
  • The role of astrocytic GABA-A receptors in postanesthetic memory deficits
  • The role of DEPTOR in Energy Balance Regulation
  • The role of epigenetics in long-term programming of NCD risk following prenatal nutritional exposures
  • The role of Glypican-6 in Recessive Omodysplasia
  • The role of matrix metalloproteinase-12 in chronic obstructive pulmonary disease: pleotropic roles revealed by terminomics.
  • The role of PCL2/PRC2 in hematopoietic stem cells and leukemia
  • The Role of Sarcolipin in Skeletal Muscle Regeneration after Acute Injury
  • Tissue-engineered in-vitro skin model to facilitate the identification of disease biomarkers for Amyotrophic Lateral Sclerosis
  • Transcriptional regulators of Leydig cell differentiation and function
  • Translational and applied genomics of pediatric malignancy
  • Translational research in pulmonary arterial hypertension
  • Traumatic Brain InjuryCognitive Rehabilitation Neuroscience
  • Typical and atypical Alzheimer Disease: salivary tau biomarkers, therapy with neuromodulation, and disease subtypes.
  • Understanding Impaired Control over Alcohol Use using the Computer-Assisted Self Administration of Ethanol Method
  • Understanding the Effects of Histone Modifications and their Symbiotic Role with Additional Genetic Aberrations in the Development of Pediatric Diffuse Intrinsic Pontine Glioma
  • Understanding the interplay different MRI methods have as white matter changes longitudinally in the cuprizone mouse model
  • Understanding the role of the MNK-eIF4E axis in the response and resistance to BRAF inhibitors.
  • Use of Transcranial Focused Ultrasound in Immunotherapy of Lewy Body Disease
  • Viral membrane fusion machines: evolution, applications, mechanism-of-action and pathogenic implications.
  • Voltage gated calcium channels: molecular targets for pain therapeutics
  • White matter integrity and sleep microarchitecture in aging and traumatic brain injury
  • Women’s Empowerment and Nutrition in the Presence of Food Insecurity: A Four-Country Cross-Sectional Study of Mothers and Children under Five in Sub-Saharan Africa

2014

  • A Scoping Review to Examine the Extent and Quality of Literature on Symptoms in Children with Rare, Progressive Disorders
  • Canada Research Chair Tier 2
  • Canadian “Rare Diseases: Models & Mechanisms” Network (RDMM) Réseau Canadien “Maladies Rares: Modèles et Mécanismes” (MRMM)
  • Chemical-genetics approaches using in vivo models of age-dependent neurodegeneration
  • CIHR Science to Business Program
  • CRC Tier 1
  • CRC Tier 2
  • Defining the role of protein arginine methyltransferases (PRMTs) and RGG/RG motifs in cancer and in the maintenance of genomic stability.
  • Delineating transforming pathways in childhood primitive neuro-ectodermal brain tumours
  • Developing a Novel Therapeutic for Cushing’s Syndrome
  • Dynein/dynactin mutations associated with amyotrophic lateral sclerosis and their effect on axonal transport and neuromuscular junction formation in the zebrafish embryo.
  • Élaboration d’un procédé de production de cellules thérapeutiques autologues destiné au traitement de la Dystrophie musculaire de Duchenne
  • Enhancement of nerve regeneration following neonatal peripheral nerve injury
  • Exercise rescues a lethal cerebellar-ataxia mouse model by upregulating Vgf – investigating the downstream molecular pathways
  • Functional characterization of the Gct1 gene product in a mouse ovarian tumour model: genetics, biology and translation
  • Genetic and functional dissection of a novel pacemaking syndrome: a model for SGOL1 mutations
  • In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders
  • Informing Future Orphan Drug Coverage Using Scenario Studies (iFOCUSS)
  • Molecular mechanism-based study for the sex-specific susceptibility in blood cancer
  • Mutant protein spread in Huntington’s disease and its implications for other neurodegenerative disorders of the CNS.
  • Next-generation sequencing elucidates the genetic aetiology of novel and rare paediatric disorders in founder populations.
  • Re-positioning clinic-ready compounds towards a cure for Duchenne muscular dystrophy
  • The role of neuronal dystonin in the autophagic process

2013

  • A Systems Genetic approach using primary cultures and genetically engineered mouse models of glioblastoma to elucidate novel pathways and therapeutic treatments
  • Adeno-associated virus gene replacement in fragile X syndrome
  • An autologous cell therapy approach to treat Duchenne muscular dystrophy using engineered muscle tissue derived from induced pluripotent stem cells
  • Cellular and Molecular Mechanisms Underlying Noonan Syndrome Cardiac Defects with RAF1 Mutations
  • Characterization of the differential roles of MyoD and myogenin in establishing the muscle gene expression program
  • Clinical, molecular and pathophysiological characterization of Pol III-related leukodystrophies
  • Clinical, Pathological, Genetic and Biomarker Studies of Frontotemporal Dementia
  • Connecting the Cell-Type Specific Chromosome Architecture to Gene Regulation, Development and Diseases
  • Control of Kidney Development by Sox4 and Sox11 Transcription Factors
  • Correction du gène de la dystrophine avec des protéines ZFNs et TALENs.
  • Defining molecular pathways underlying craniofacial birth defects
  • Determine the functional role of Xin within skeletal muscle in vivo
  • Development of a treatment for Friedreich ataxia based on the administration of TALE proteins targeting the frataxin promoter.
  • Directing Cellular Identity to Move Towards Progenitor Cell Therapies
  • Enhanced CARE for RARE Genetic Diseases in Canada
  • Evaluating the Impact of Moral Arguments on Societal Values for Orphan Drug Coverage
  • Evaluating the Mechanism of Action of Small Molecule Modulators of CFTR
  • Genetic analysis of Williams-Beuren syndrome: linking genes with behaviour and cognition
  • Inherited bone marrow failure syndromes: from genomic discoveries to biology
  • iPS cells to model vascular disease in patients with Williams Beuren syndrome
  • Loss of VAPB Function in Amyotrophic Lateral Sclerosis-8 (ALS8)
  • Molecular role of MLIP in myoblast differentiation and regeneration.
  • PAX6 gene therapy rescue of mouse small eye
  • Re-activation of human endogenous retrovirus-K in Amyotrophic Lateral Sclerosis: A consequence of genetic mutations in TDP43 and Optineurin.
  • Regulation of Skeletal Muscle Stem Cell Activity by microRNA and Cytoplasmic mRNP Granules
  • Role of RhoGDIalpha in the pathogenesis of congenital and childhood nephrotic syndrome
  • Scleroderma Patient-centered Intervention Network (SPIN) Project Development Meeting
  • Search for non-coding mutations in patients with cblC and mut inborn errors of cobalamin metabolism
  • Synaptic targets for therapeutic protection of motor function in a genetic model of ALS
  • The neurological correlates of motor and cognitive decline in ALS
  • The Peroxisome Biogenesis Disorders: From Bench to Bedside
  • The role of Wnt7a in skeletal muscle
  • The roles of MBNL proteins in the pathogenesis of myotonic dystrophy
  • Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.

2012

  • A small molecule inhibitor of G protein-coupled Receptor Kinase 6 (GRK6) to treat human Multiple Myeloma and related diseases
  • Applied clinical informatics for genome analysis of patients with treatable intellectual disabilities
  • Biological mechanisms contributing to increased risk of facial clefting
  • Can laminin-111 be used to treat Duchenne Muscular Dystrophy alone or in combination with myoblast transplantation?
  • CANADA RESEARCH CHAIRHOLDER/TITULAIRE DES CHAIRES DE RECHERCHE DU CANADA
  • Cardiolipin synthesis as a therapy for heart failure in persistent pulmonary hypertension
  • Cardiovascular autonomic control in acute spinal cord injury
  • Cell biological mechanisms of TDP-43 in amyotrophic lateral sclerosis
  • Cellular and synaptic mechanisms of TDP-43 proteinopathy using zebrafish.
  • Characterization of the Pol III-related hypomyelinating leukodystrophies
  • Choroideremia: expanding our understanding, exploring treatments
  • Chronic childhood vasculitis: Characterizing the individual rare diseases to improve patient outcomes
  • Comparison of methods to synthesize clinical and economic information for the health technology assessment of novel drugs used in small patient populations with methods used in larger clinical populations and communication of this information to decision makers.
  • Congenital Heart Block International Research Network (CIRN)
  • Correction of the dystrophin gene with Zinc Finger Proteins and TAL effector nuclease
  • Developing a Canadian framework for evaluation and decision-making for expensive drugs for rare diseases through innovation, value, and priority setting
  • Developing Effective Policies for Managing Technologies for Rare Diseases
  • Discovering new genes for tetralogy of Fallot and cardiac development
  • Elucidating the Protective Mechanism of Phospho-N17 Huntingtin in Huntington’s disease
  • Emerging team in rare diseases: achieving the “triple aim” for inborn errors of metabolism
  • Emerging Team to identify and characterize novel and existing Hereditary Spastic Paraplegia (HSP) disease genes
  • Emerging Team: The Scleroderma Patient-centered Intervention Network
  • Enhanced CARE for RARE Genetic Diseases in Canada
  • Enzyme Enhancement Therapy for GM1 gangliosidosis
  • Experimental Therapies to prevent pulmonary hypertension and promote lung vascular growth in congenital diaphragmatic hernia
  • Français: “Caractérisation d’un nouveau gène important pour le développement du système nerveux entérique.” Anglais: “Characterization of a novel gene required for proper development of the enteric nervous system.”
  • Functional analysis of non-coding RNA/chromatin interactions at imprinted Prader-Willi Syndrome locus
  • Functional Dissection of Small RNA Pathways that Impact Chromatin
  • Genetic Regulation of Myogenesis
  • Growth arrest and osteoporosis in Duchenne muscular dystrophy patients treated with glucocorticoids
  • Identification and Characterization of New MicroRNA Biomarkers in Chronic Myeloid Leukemia Stem Cells: Clinical Applications and Pathogenic Significance
  • Identifying novel roles of calcineurin signaling in the control of multiple complementary pathways affecting the dystrophic phenotype
  • Improving design and analysis of longitudinal studies of prognosis in uncommon diseases
  • Improving Muscular Dystrophy Cell Therapy with Drug-Related Gene Knock-Down in Donor Cells
  • Magnetic resonance imaging biomarkers in ALS
  • Misfolding of Cu/Zn superoxide dismutase by pathological FUS and TDP43: relevance to amyotrophic lateral sclerosis
  • Molecular Mechanisms of Ventilator-Induced Diaphragm Dysfunction in Human
  • Molecular regulation of asymmetric satellite stem cell division
  • Molecular regulation of progenitor cell behaviour in the developing retina
  • Molecular regulation of skeletal muscle stem cells
  • Molecular role of MLIP in myoblast differentiation and regeneration.
  • Molecular Targeting of Critical Domains of AHI-1 Oncoprotein in Chronic Myeloid Leukemia Stem Cells Resistant to Current Tyrosine Kinase Inhibitor Therapy
  • Mucopolysaccharidosis I Disease: Tools for Discovery and Design of Chaperone Therapeutics Based on Unique Enzyme Production Systems and the Elucidation of the Structure of alpha-L-Iduronidase
  • New directions for the use of genetic information by Aboriginal communities: Lessons learned from Québec First Nations with specific monogenic diseases.
  • New emerging team on Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS): from models to treatment strategies
  • Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
  • Planning Meeting for Developing a Canadian framework for reimbursement decision-making for expensive drugs for rare diseases
  • Plasticity and Sensitivity of Renal Cell Carcinoma Cancer Stem Cells
  • Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy
  • Prognostic markers and biology of relapsed Hodgkin lymphoma
  • Regeneration of motor neurons controlling movement and respiration from embryonic stem cells
  • Regulation of motor neuron identity and circuit development
  • Roles of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy
  • Sapropterin for treatment of patients with Phenylketonuria: Identification of subpopulations with substantial clinical benefit
  • Sepsis-induced skeletal muscle dysfunction: Role of autophagy
  • SIX family transcription factors in adult muscle regeneration
  • TDP-43-mediated pathogenic pathways in ALS and new experimental therapeutics
  • The CHAPTER Study: Congenital Heart Adolescents Participating in Transition Evaluation Research
  • The FACTs Project: FAbry disease Clinical research and Therapeutics
  • The ICHANGE (International CHildhood Astrocytomas iNtegrated Genomics and Epigenomics) Consortium
  • The role of autophagy and posttranslationally myristoylated huntingtin in Huntington disease.
  • The role of post-translational modifications of MRE11 in mediating the DNA damage response.
  • The role of the transcriptional co-repressor RIP 140 in muscular dystrophy: a therapeutic target?
  • The use of Next Generation Exome sequencing in the identification of genes responsible for rare childhood neurologic disorders
  • Towards Therapeutics For Genetic Corneal Dystrophies
  • Understanding the pathophysiology of Rasmussen’s encephalitis

2011

  • A novel investigation of functional pathoanatomy and outcomes of lumbar spinal stenosis 5 years following diagnosis
  • Abnormal Activation of Thymocytes High-Mobility Group Box Protein (TOX) in Cutaneous T Cell Lymphomas: Pathogenic Significance and Clinical Applications
  • CD123-Targeted Auger Electron Radioimmunotherapy of Acute Myelogenous Leukemia (AML)
  • Cellular lipids in Huntington’s disease
  • Characterization of skeletal muscle inflammation, fibrosis, degeneration and atrophy in response to mycobacterium ulcerans infection
  • Characterization of the formation of protein aggregates induced by the inhibition of the ubiquitin proteasome system
  • CIHR Secondary Analysis of Databases: Canadian Pediatric Surgery Network (CAPSNet)
  • Detection and simulation of femoroacetabular impingement
  • Development of ganglioside-based therapies for Huntington’s disease
  • Effects of a Gja1 (gap junction protein alpha1, Connexin 43) gene missense mutation on mesenchymal stem and progenitor cells in a mouse model of human oculodentinodigital dysplasia (ODDD)
  • Establishing a community-based Long QT resource team: informing the needs of a community at risk
  • Exploring the functions of the Bub1 and BubR1 kinases during mitosis
  • Finding of Rare Disease Genes in Canada (FORGE Canada)
  • Functional characterization of microRNAs in acute myeloid leukemia stem cells
  • Generation of a humanized mouse xenotransplant model of myelodysplastic syndrome.
  • Glia-neuron crosstalk in early amyotrophic lateral sclerosis pathogenesis
  • Identification and characterization of the gene responsible for autosomal dominant spinocerebellar ataxia in the Franco-Ontarian population
  • Identification of novel genes causing pulmonary fibrosis
  • Investigation into the cause of Myoclonus Dystonia
  • Maternal Diabetes and Perinatal Programming: Role of Reactive Oxygen Species
  • Mechanisms that Regulate Peroxisome Turnover and their role in Neurodegenerative Diseases
  • Mitochondrial dysfunction and brain energy metabolism in the pathogenesis of Niemann-Pick Type C disease
  • Molecular Mechanisms of Protein Sorting in the Endocytic Pathway
  • Multigenic analysis and chemical drug screening using in vivo zebrafish models of motor neurodegenerative disorders
  • Muscle rehabilitation of cerebral palsy patients recieving botulinum toxin type-A (Botox) treatments
  • Next-Generation-Sequencing Human Exome pour la découverte de nouveaux gènes impliqués dans les paraplégies spastiques familiales
  • Novel anti-inflammatory treatment for Amyotrophic Lateral Sclerosis
  • Nuclear envelopathy in Amyotrophic Lateral Sclerosis-8 (ALS8)
  • Obstetrical Complications and Long-Term Outcomes of Children Born to Women with Systemic Lupus Erythematosus (SLE)
  • Pathogenesis and Etiology of Congenital Diaphragmatic Hernia
  • Physiological functions of the cellular prion protein
  • Preclinical assessment of clinic ready agents for the treatment of muscular dystrophy and spinal muscular atrophy
  • Preclinical Assessment of Rho-kinase Inhibitors for Chronic Pulmonary Hypertension
  • Prion-like intermolecular transmission of superoxide dismutase 1 (SOD1) misfolding in embryonic spinal cord cultures of an amyotrophic lateral sclerosis (ALS) mouse model.
  • Regulation of type 1 cannabinoid receptor expression in Huntington’s disease.
  • Role of calcineurin and its signaling modulators in the dystrophic phenotype
  • Role of endoglin in aberrant TGF-beta signaling in scleroderma
  • Role of energy balance in age-dependant neurodegeneration and stress response in C.elegans
  • Role of G-protein-coupled receptor kinase 2 (Gprk2) in Hedgehog signaling
  • Role of progranulin in the TDP-43/FUS pathway in Amyotrophic Lateral Sclerosis (ALS) pathogenesis
  • Role of Xin, an actin-binding protein, in satellite cells and muscular dystrophies
  • Satellite Stem Cells from Skeletal Muscle for the Treatment of Neuromuscular Disease
  • Specific Targeting of Monomeric SOD1 as a Potential Immunotherapeutic Strategy for ALS.
  • Strategies for therapy of respiratory muscle failure in muscular dystrophy
  • Studies on the molecular pathogenesis of Amyotrophic Lateral Sclerosis
  • Targeting of protein phosphatase 1beta to nuclear actin and myosin.
  • The function of Wnt signaling via ß-catenin during myogenesis in mouse embryonic stem cells
  • The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis
  • Tissue Engineering Therapies for Bone Regeneration in Cleft Palates
  • Using proteomics to investigate the role of TDP-43 (TAR DNA-binding protein 43) in the pathogenesis of Amyotrophic Lateral Sclerosis

2010

  • Altered balance of synaptic/extrasynaptic NMDA receptor signaling in Huntington disease
  • Artificial zinc finger transcription factors targeting the utrophin promoter as a potential therapy for Duchenne muscular dystrophy
  • Characterization of a novel function for PABPN1: the product of the oculopharyngeal muscular dystrophy disease gene
  • Characterization of the causative genes and investigation of their role in the development of two new forms of muscular dystrophy in the French-Canadian population.
  • Chromatin Immunoprecipitation to identify direct targets of MyoD in mouse embryonic stem cells
  • Development of a novel therapy for treatment of Spinal Muscular Atrophy
  • Discovering the therapeutic potential of neurotrophin antagonists in Amyotrophic Lateral Sclerosis
  • Ensuring effective newborn screening: The case of cystic fibrosis
  • Epithelial-mesenchymal (endothelial)interactions regulate postnatal lung development
  • Études fonctionnelle des variants d’épissage de FANCA et effets sur la réparation de l’ADN
  • Exploiting skeletal muscle as a therapeutic target to treat Spinal Muscular Atrophy
  • Fanconi Anemia signaling and Mus81-Eme1: role in replicative stress and development
  • Full-Length Huntingtin Protein has a Critical Function in Cell Heat Shock Stress Response that is Affected in Huntington’s Disease.
  • Functional Architecture of the CFTR Chloride Channel
  • Genome-wide analysis of bone marrow failure-related genetic alterations in inherited bone marrow failure syndromes
  • Genome-wide exon capture for targeted resequencing in patients with familial amyotropic lateral sclerosis
  • Investigation of FMRP-related changes in dendritic morphology and intrinsic properties of ACC pyramidal cells
  • Involvement of planar cell polarity pathway in glomerular disease
  • Involvement of planar cell polarity pathway in glomerular disease
  • Lymph Node Conservation: A Potential New Therapy for the Prevention of Post-Surgical Lymphedema.
  • MicroRNA (miRNA) modulation of NFL mRNA degradation and translational silencing in ALS
  • Molecular basis of memory defects in Drosophila Fragile X mutants
  • Molecular Determinants of Li-Fraumeni Syndrome Associated Cancers
  • Molecular mechanisms of organelle inheritance
  • Motor, multisystemic and social participation assessment in myotonic dystrophy type 1: a 9-year longitudinal study
  • Pathobiology and ribosomal insufficiency in Shwachman-Diamond syndrome
  • Pathogenesis of striated muscle specific laminopathies: defining the developmental role of LITF in myogenesis and muscle regeneration.
  • Pathogenic mechanisms associated with neurofilament disorganization
  • Promoting protection of functionally intact motor units in amyotrophic lateral sclerosis (ALS)
  • Protein transport into and across cellular membranes
  • Role and signaling mechanism of EAT-2, an adaptor involved in anti-tumor immunity
  • Role of the RNA-binding protein Staufen1 in Myotonic Dystrophy type 1
  • The functional role of a H2AX promoter polymorphism associated with non-Hodgkin lymphoma
  • The molecular mechanisms of microgliosis in GM2 ganglioside lysosomal storage diseases
  • The role of TNFalpha in synaptic plasticity and during neurodegeneration
  • The Terry Fox New Frontiers Program Project in genomics of forme fruste tumours: new vistas on cancer biology and management
  • Towards Enzyme Enhancement Therapy for Gaucher Disease