A Realist Synthesis of Housing First Programs: What Works, for Whom, Under What Circumstances in the Community Functioning of Formerly Homeless Adults
Defining the role of schwann cell precursors in neural repair.
Identification of GBM genetic wiring vulnerabilities.
Investigation of premature-aging like phenotypes in ATRX mutant mice
Life course-adjusted associations between intrauterine environment and DNA methylation in young adult women of a Jerusalem Perinatal Study sub-cohort.
Molecular detection of known and novel cancer predisposition genes
OSMR Signalling in Glioblastoma Pathogenesis
Personalizing Inhaler Therapy For Men and Women With Chronic Obstructive Pulmonary Disease (COPD)
Unraveling the Genetic Architecture of Specific Language Impairment
2015
A collaborative filtering based approach to biomedical knowledge discovery
A longitudinal study of DNA methylation in women with Anorexia Nervosa: Roles of disorder chronicity, nutritional status and weight restoration
A personalized allele-specific gene silencing approach for maximal therapeutic coverage of the Huntington disease population
Accelerating vascularization and blood perfusion for cell transplantation and myocardial regeneration
Acceleration of Tooth Movement in Bisphosphonate Burdened Alveolar Bone
Activation of SREBP2 activity in the absence of calreticulin
Adaptation of Bacterial Pathogens
Aging effects on components of locomotion, and the impact of increased regular physical activity beginning in late adulthood
Anaerobic eukaryotic microbes and the human microbiome: a genomic and metagenomic study
Apolipoprotein A-I and apolipoprotein E4 in cerebrovascular health and Alzheimer’s disease pathogenesis
Aripiprazole Long Acting Injectable (ALAI), its potential enhancing effect on memory and associated neural structures: A longitudinal brain imaging study in first-episode psychosis
Ascending aortic dilation in patients with bicuspid aortic valve disease is marked by accelerated vascular smooth muscle cell aging.
Assessing the effectiveness of an online educational intervention to promote skin self-examination among melanoma survivors: A randomized controlled trial
Atomic resolution pharmacology of anti-epileptic drugs
Behavioural Experiments for Intolerance of Uncertainty: A Single-Component Treatment for Generalized Anxiety Disorder
Better Prediction and Decision Support Tools to Improve Care and Outcomes for Patients with Acute Kidney Injury (AKI)
Bioinformatic and functional approaches to cancer pharmacogenomics
Biomarker Discovery for Stress Related Diseases Using Nuclear Magnetic Resonance Spectroscopy
Bridging discovery to clinic: from biomarkers to therapeutic developments in ovarian cancer
Canada Research Chair in Molecular Genetics
Canada Research Chair in Molecular Hemostasis
Canada Research Chair Tier 1
Canada Research Chair Tier 2
Canadian Glycomics Network (GlycoNet)
Cell size specification in normal and malignant populations
Central control of osmoregulation in health and disease
Characterization of a Novel Bi-genic Mouse Model of Parkinsonism and Dementia with Lewy Bodies
Characterizing mechanism of inhibition of Cathepsin K by novel exosite inhibitors
Characterizing the role and regulation of the mammalian tumour suppressor gene Fat4 on metabolism, mitochondrial complex activity and stability
Close encounters of a Natural Killer kind: Understanding how NK cells protect against HIV infection.
Cocooning Therapeutic Cells
Cognitive Behavior Therapy for Anxious and Depressed Youth: Improving Outcomes through Mobile Technology
Cognitive training in patients with Parkinson’s disease and healthy controls
Combining Genomics and Phenomics to identify genes associated with human sensory disorders
Common Pathogenic Pathways and Therapeutics for SMA and ALS motoneuron diseases
Community, research and public partnerships: A multimedia photo essay exhibit exploring the role of place in shaping the life chances and health outcomes of young people who are living with or at risk of HIV in Vancouver
Computation and theory to predict structures and mechanisms for protein misfolding in amyotrophic lateral sclerosis
Consequences of Excessive Exercise for Cardiac Arrythmogenesis: What is the Role of Acute and Chronic Inflammation?
Copy number variations (CNVs) and colorectal cancer
Dclk1+ tuft cells as a cellular origin for inflammation-associated cancer in the gut
Deciphering the functional role of Viral protein R (Vpr) during HIV infection
Deciphering the metabolic signatures of the metabolic syndrome (MetS) in young children
Delivery of CD109-based peptides to antagonize TGF-beta in a murine model of wound healing
Des institutions et des femmes : Évolution du nursing psychiatrique au Québec, 1912-1974
Determinants of Smoking Cessation Success in the Mass Distribution Paradigm of Nicotine Replacement Therapy
Developing a Science of Global Health Strategy
Developing an optogenetically-inspired deep brain stimulation protocol to normalize synaptic transmission and abolish pathological behaviour in a SAPAP3 knock-out model of obsessive-compulsive disorder
Developing evidence for more effective handrail design to prevent falls and inform changes in the Canada Building Code
Development of Genomic and Bioinformatic Tools and Methodologies to Identify Potential Drug Targets for Aortic Stenosis Therapeutics
Developmental neurogenetics of schizophrenia: Connecting genetic risk profile scores with hippocampal structure and functioning across the lifespan
Développement, optimisation et multiplexage d’un oligonucléotide synthétique permettant l’amplification d’ADN et l’hybridation sur support solide en une seule étape. PDP PhaseI
Differences in genetic and diet-induced obesity modulate susceptibility to enteric infection
Discovering Spatial Epigenetics
Discovery of Novel Resistance Mechanisms against Regulatory T-cells in Tumour Microenvironment
Discovery of Novel Therapeutic Targets in Osteosarcoma
Dissection of the molecular mechanisms controlling the establishment of neuronal circuitry during development
Dynamics of cell-to-cell mediated HIV-1 spread in the lymph node
Economic evaluation of a point-of-care transfusion algorithm in cardiac surgery
Effect of the gut microbiota and their generated metabolites on HIV-1 biology in CD4+ T cells
Effectiveness of interventions for implementation of thromboprophylaxis in hospitalized patients at risk for venous thromboembolism: An updated systematic review and metaanalysis
Effects of Housing First on employment and income of homeless individuals: results of a randomized trial
Effects of shear stress on atherosclerotic plaque regression
Effet de l’âge des culots globulaires transfusés sur le pronostic neurologique suivant un traumatisme craniocérébral (Étude ABLE-tbi)
Efficacy and Mechanism of Action of Novel Nucleoside Analogues Against Solid Tumours
Elucidating the cause of multiple system atrophy in a Korean cohort
Elucidating the Gene-Environment Interactions that drive Autoimmune Disease among South Asian Canadians – The GEMINI Program.
Elucidation of regulatory mechanisms modulating STAT3 expression during cancer-induced muscle atrophy
Epigenetic and Transcriptomic Disturbances in HIV-Associated COPD
Epigenetic Regulation of Muscle Regeneration in Health and Disease
Epigenetic Regulation of the Adenovirus Genome
Establishing donor-specific transplantation tolerance by harnessing DN regulatory T cells
Exome sequencing of patients with Weaver-like features links another cancer gene, EED, to overgrowth syndromes.
Exploring Gene/Environment Interaction in the Diabetic Embryopathy Femoral Facial Syndrome
Extending circulation time of protein therapeutics by capping glycan structures with 7F-Sialic acids
Factors regulating establishment and maintenance of HIV provirus latency
Family-based obesity prevention: Identifying effective strategies through epidemiologic research and intervention trials
Functional and genomic clonal analysis of human glioblastoma
Functional characterization of new regulators of the innate antiviral immunity to develop broad-spectrum antiviral therapies
Gata3 and the transciptional control of nephric duct morphogenesis
Gene Environment Team on Brown/beige Adipose Tissue (GET_BAT)
Genetic and genomic analysis of bacterial cell morphogenesis
Genetics of Obesity
Gfi1, a new regulator of the DNA Damage Response Pathway in T lymphocytes and T cell Leukemia
How a Novel Innate Immune Regulatory Factor Affects Liver Cholesterol and Triglyceride Homeostasis
Human Cancer Stem Cell Biology
Identification and evaluation of novel therapeutics for myotubular myopathy
Identification of new microRNA biomarkers and candidate target genes in primitive CML cells using global comparative RNA analyses
Identification of Putative Diagnostic Biomarkers for Breast Cancer through Kinome Analysis
Identifying and Planning Research Opportunities in Pediatric Antimicrobial Stewardship: A National Collaboration
Identifying High Risk Subsets of Spinal Surgery Patients: Poor Post-Surgical Outcomes and Long-term Opioid Analgesic Use.
Immunologial memory of innate lymphocytes and allergic lung inflammation
Immunotherapy of familial prion diseases
Impact d’un programme d’entraînement sur les déterminants de la consommation d’oxygène maximale chez les patients obèses sévères à 3 et à 6 mois suivant soit une dérivation biliopancréatique avec commutation duodénale ou une gastrectomie pariétale
Impact of VEPH1 on cancer associated signaling pathways in the promotion of ovarian cancer
Impact of VEPH1 on cancer associated signaling pathways in the promotion of ovarian cancer
Implementation and Commercialization of a Novel DNA Methylation-Based Diagnostic Tool
Implementation and ethical dimensions of scaling up HIV treatment as prevention (TasP)
Importance of tissue-resident memory (Trm) CD8 T cells in controlling SIV infection in mucosal sites of viral entry
Improving Depression Screening by Reducing Bias in Accuracy Estimates: An Independent Patient Data Meta-Analysis of the Edinburgh Postnatal Depression Scale (EPDS)
Improving hematologic cancer survivors’ health through physical activity: Translating intentions into exercise
Incorporating patient preferences into health outcome assessment and economic evaluation for breast cancer: The BREAST-Q Utility Index
Innovative chemogenomic tools to improve outcome in acute myeloid leukemia
Integrated Genomic and Epigenomic Analysis of Regulatory Elements in Glioblastoma
Interpreting genomic data through the study of methylome in Autism Spectrum Disorder
Investigating a tumor suppressor role for Parkinson’s susceptibility gene LRRK2 in lung cancer
Investigating the Pathophysiology and Treatment of Parkinson’s Disease using 3D Cell Co-Cultures
Investigating the role of Staphylococcus aureus IsdB protein in the mechanism for heme-uptake from human hemoglobin.
Investigating the use of Smac mimetic compounds combined with innate immune stimuli to induce rhabdomyosarcoma cell death
Investigation of premature-aging like phenotypes in ATRX mutant mice
Investigation of the sequential development of integrase strand transfer inhibitor resistance mutations in HIV.
Investigations of low energy electron damage to DNA: application to Chemoradiation therapy.
Linking gene expression to neuronal behaviour in normal and disordered brains through large-scale meta-analysis
Lipid metabolism, insulin secretion and energy homeostasis
Long QT Syndrome in Northern British Columbia: Predicting Risk for sudden death
Maintenance of Polycomb Group protein mediated repression through mitosis.
Mechanisms and Risk Stratification for Treatment of Acute Myeloid Leukemia in Children with Down syndrome
Mechanisms governing Hepatitis C virus genome stability and viral RNA accumulation
Mechanisms of HDL induced signaling in vascular cells and role in protection against coronary artery atherosclerosis.
Mesures optiques des processus de plasticité synaptique
Misutilization of laboratory tests: pathways to correction
Mitochondrial origins of pathological angiogenesis in Age-Related Macular Degeneration
Modelling mechanisms of resistance and predictive biomarker discovery against targeted therapy using human primary non-small cell lung cancer xenografts.
Modulation of the DNA damage repair (DDR) response in the treatment of brain tumours
Modulators of epigenomic processes – a novel approach to cancer therapy
Molecular analysis of Herpes simplex virus type I egress
Molecular and Genomic Pathology
Molecular Brake Mechanisms That Regulate Brain Plasticity and Disease
Molecular Determinants of the Li-Fraumeni Syndrome
Mutations in a long non-coding RNA cause Myoclonus Dystonia
Neurovasculature and hippocampal integrity in early psychosis
New mechanisms of podocyte injury in diabetic nephropathy
Novel Regulators of Mitochondrial Dynamics
Novel therapeutic targets for CCNE1-amplified high-grade serous ovarian carcinomas
Novel Therapies for Cystinosis
Optically-Guided Biopsy for Improved Diagnosis of Peripheral Pulmonary Nodules
Optogenetic Activation Of Hypothalamic Dopamine A11 Neurons Rescues Cataplexy In Narcoleptic Mice
OSMR Signalling in Glioblastoma Pathogenesis
P2 purinoceptors in the spinal dorsal horn
Pannexin-1 channels as therapeutic targets in post-stroke neuroinflammation
PARTNERS – Patient Assisted Research Transforming National Effectiveness in Rare Diseases. Creating Pathways Toward Improved Care Delivery, Outcomes and Reduced Burden.
Pathobiology of renal dysplasia: a functional role for stromally expressed beta-catenin
Peroxisomes in Health and Disease
Personalized medicine in the treatment of epilepsy
Pharmacogenetics of Antipsychotic Treatment Response in Schizophrenia
Pharmacological suppression of cerebral cavernous malformations
PKCs as molecular memory traces
Platelets and their microparticles: versatile players of inflammation
POLR3-related leukodystrophy: From bench to bedside
Potential mechanism for ribbon repair after noise induced synaptic damage in the cochlea
Probing and Characterizing Resistance to Integrase Inhibitors Using Simian Immunodeficiency Virus 239
Promoting Appropriate Body Weight and Optimal Dietary Intake to Pregnant and Postpartum Women in the Context of Community-Based Organizations in Alberta
Quantitative Magnetic Resonance Imaging of Brain Structure and Function
Quantitative MR Imaging of Vascular Contributions to Aging, Cognitive Decline and Stroke
Recombinant hydrolases as anti-biofilm therapies for Aspergillus infections
Regenerative Cardiovascular Medicine
Regulation of Myogenin by acetyltransferase p300 during myogenic differentiation
Repurposing biomolecules for the treatment of epidermolysis bullosa
Respiratory mucosal immune responses to environmental exposures relevant in airway health and disease.
Rôle de CREB et de ses gènes cibles dans la mémorisation d’une tâche motrice
Role of autophagy in Helicobacter pylori infection and disease
Role of eurkaryotic elongation factor-2 kinase (eEF2K) in Alzheimer’s disease and relevance for novel therapies.
Role of heme oxygenase system in cardiac regeneration and repair in obese Zucker fatty rats
Role of oncogenic transcription factors in T-cell acute lymphoblastic leukemia
Role of PVRL4 (Nectin-4) receptor in measles virus infections and oncolytic therapy
Role of SIX family transcription factors in proliferation and tissue regeneration.
Role of small regulatory RNAs expressed by the intracellular pathogen Legionella pneumophila.
Ryanodine receptor mutations in stress-induced arrhythmia: correlating molecular structure with disease phenotype
Sensori-motor integration in trigeminal circuits of the masticatory central pattern generator
Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older adults
Slit-Robo Signalling in Atherogenesis
Social identity, depression, and the role of the oxytocin receptor gene
Strengthening Global Systems to Protect Children: A multi-national analysis of HIV risk and violence against children
Stromal influence on epithelial outgrowth and heterogeneity in breast cancer
Structural and functional studies at the HIV-1 viral infectivity factor-APOBEC3 axis
Structural and functional studies of rhomboid protease PARL (Presenillin-Associated Rhomboid-Like) in Parkinson’s disease
Structure-based Antibiotic Discovery on the Bacterial Membrane
System Immunobiology of S. aureus pathobiosis: Role of the AhR Gene Program
T cell costimulatory signalling in disease progression of angioimmunoblastic T cell lymphoma
Targeted intrapulmonary delivery of antiviral and immunomodulatory therapeutics to alleviate severe experimental H7N9 influenza-induced pneumonia
Targeting Cancer Drug Resistance: Bioflavonoid-Stimulated Glutathione Efflux by Multidrug Resistance Protein 1
Targeting Cell Death Signaling Pathways in the Heart
Targeting Colorectal Cancer stem cells self-renewal through EZH2 and PRMT5.
Targeting ETS Factor ERG as a Novel Therapeutic for the Treatment of Prostate Cancer
Targeting Invadopodia as an Anti-Metastatic Therapy in Breast and Prostate Cancer.
Targeting TAZ and YAP: a new approach to anti-fibrotic therapy in the kidney
Targeting the tumour cell stress response in high-risk childhood cancers
Telomere Length, Stress, and Social Support in Survivors of Paediatric Cancer and their Parents
The application of next-generation sequencing technology in identifying the genetic origins of unclassified familial disorders.
The development of dysregulation from 3 months to 6 years of age: The interplay of plasticity genes, pre- and postnatal exposure, and early mother-child interaction
The Influence of Genetic Risk Factors and Early Life Stress on Myelin Integrity Changes in Depression and Prediction of Treatment Response
The regenerative effects of the trophic cytokines granulocyte macrophage-colony stimulating factor and erythropoietin in murine model of Parkinson’s disease.
The RGS2-eIF2B binding domain (RGS2eb) as a novel inhibitor of pathological cardiac hypertrophy
The role of astrocytic GABA-A receptors in postanesthetic memory deficits
The role of DEPTOR in Energy Balance Regulation
The role of epigenetics in long-term programming of NCD risk following prenatal nutritional exposures
The role of Glypican-6 in Recessive Omodysplasia
The role of matrix metalloproteinase-12 in chronic obstructive pulmonary disease: pleotropic roles revealed by terminomics.
The role of PCL2/PRC2 in hematopoietic stem cells and leukemia
The Role of Sarcolipin in Skeletal Muscle Regeneration after Acute Injury
Tissue-engineered in-vitro skin model to facilitate the identification of disease biomarkers for Amyotrophic Lateral Sclerosis
Transcriptional regulators of Leydig cell differentiation and function
Translational and applied genomics of pediatric malignancy
Translational research in pulmonary arterial hypertension
Typical and atypical Alzheimer Disease: salivary tau biomarkers, therapy with neuromodulation, and disease subtypes.
Understanding Impaired Control over Alcohol Use using the Computer-Assisted Self Administration of Ethanol Method
Understanding the Effects of Histone Modifications and their Symbiotic Role with Additional Genetic Aberrations in the Development of Pediatric Diffuse Intrinsic Pontine Glioma
Understanding the interplay different MRI methods have as white matter changes longitudinally in the cuprizone mouse model
Understanding the role of the MNK-eIF4E axis in the response and resistance to BRAF inhibitors.
Use of Transcranial Focused Ultrasound in Immunotherapy of Lewy Body Disease
Viral membrane fusion machines: evolution, applications, mechanism-of-action and pathogenic implications.
Voltage gated calcium channels: molecular targets for pain therapeutics
White matter integrity and sleep microarchitecture in aging and traumatic brain injury
Women’s Empowerment and Nutrition in the Presence of Food Insecurity: A Four-Country Cross-Sectional Study of Mothers and Children under Five in Sub-Saharan Africa
2014
A Scoping Review to Examine the Extent and Quality of Literature on Symptoms in Children with Rare, Progressive Disorders
Canada Research Chair Tier 2
Canadian “Rare Diseases: Models & Mechanisms” Network (RDMM) Réseau Canadien “Maladies Rares: Modèles et Mécanismes” (MRMM)
Chemical-genetics approaches using in vivo models of age-dependent neurodegeneration
CIHR Science to Business Program
CRC Tier 1
CRC Tier 2
Defining the role of protein arginine methyltransferases (PRMTs) and RGG/RG motifs in cancer and in the maintenance of genomic stability.
Delineating transforming pathways in childhood primitive neuro-ectodermal brain tumours
Developing a Novel Therapeutic for Cushing’s Syndrome
Dynein/dynactin mutations associated with amyotrophic lateral sclerosis and their effect on axonal transport and neuromuscular junction formation in the zebrafish embryo.
Élaboration d’un procédé de production de cellules thérapeutiques autologues destiné au traitement de la Dystrophie musculaire de Duchenne
Enhancement of nerve regeneration following neonatal peripheral nerve injury
Exercise rescues a lethal cerebellar-ataxia mouse model by upregulating Vgf – investigating the downstream molecular pathways
Functional characterization of the Gct1 gene product in a mouse ovarian tumour model: genetics, biology and translation
Genetic and functional dissection of a novel pacemaking syndrome: a model for SGOL1 mutations
In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders
Informing Future Orphan Drug Coverage Using Scenario Studies (iFOCUSS)
Molecular mechanism-based study for the sex-specific susceptibility in blood cancer
Mutant protein spread in Huntington’s disease and its implications for other neurodegenerative disorders of the CNS.
Next-generation sequencing elucidates the genetic aetiology of novel and rare paediatric disorders in founder populations.
Re-positioning clinic-ready compounds towards a cure for Duchenne muscular dystrophy
The role of neuronal dystonin in the autophagic process
2013
A Systems Genetic approach using primary cultures and genetically engineered mouse models of glioblastoma to elucidate novel pathways and therapeutic treatments
Adeno-associated virus gene replacement in fragile X syndrome
An autologous cell therapy approach to treat Duchenne muscular dystrophy using engineered muscle tissue derived from induced pluripotent stem cells
Cellular and Molecular Mechanisms Underlying Noonan Syndrome Cardiac Defects with RAF1 Mutations
Characterization of the differential roles of MyoD and myogenin in establishing the muscle gene expression program
Clinical, molecular and pathophysiological characterization of Pol III-related leukodystrophies
Clinical, Pathological, Genetic and Biomarker Studies of Frontotemporal Dementia
Connecting the Cell-Type Specific Chromosome Architecture to Gene Regulation, Development and Diseases
Control of Kidney Development by Sox4 and Sox11 Transcription Factors
Correction du gène de la dystrophine avec des protéines ZFNs et TALENs.
Determine the functional role of Xin within skeletal muscle in vivo
Development of a treatment for Friedreich ataxia based on the administration of TALE proteins targeting the frataxin promoter.
Directing Cellular Identity to Move Towards Progenitor Cell Therapies
Enhanced CARE for RARE Genetic Diseases in Canada
Evaluating the Impact of Moral Arguments on Societal Values for Orphan Drug Coverage
Evaluating the Mechanism of Action of Small Molecule Modulators of CFTR
Genetic analysis of Williams-Beuren syndrome: linking genes with behaviour and cognition
Inherited bone marrow failure syndromes: from genomic discoveries to biology
iPS cells to model vascular disease in patients with Williams Beuren syndrome
Loss of VAPB Function in Amyotrophic Lateral Sclerosis-8 (ALS8)
Molecular role of MLIP in myoblast differentiation and regeneration.
PAX6 gene therapy rescue of mouse small eye
Re-activation of human endogenous retrovirus-K in Amyotrophic Lateral Sclerosis: A consequence of genetic mutations in TDP43 and Optineurin.
Regulation of Skeletal Muscle Stem Cell Activity by microRNA and Cytoplasmic mRNP Granules
Role of RhoGDIalpha in the pathogenesis of congenital and childhood nephrotic syndrome
Scleroderma Patient-centered Intervention Network (SPIN) Project Development Meeting
Search for non-coding mutations in patients with cblC and mut inborn errors of cobalamin metabolism
Synaptic targets for therapeutic protection of motor function in a genetic model of ALS
The neurological correlates of motor and cognitive decline in ALS
The Peroxisome Biogenesis Disorders: From Bench to Bedside
The role of Wnt7a in skeletal muscle
The roles of MBNL proteins in the pathogenesis of myotonic dystrophy
Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.
2012
A small molecule inhibitor of G protein-coupled Receptor Kinase 6 (GRK6) to treat human Multiple Myeloma and related diseases
Applied clinical informatics for genome analysis of patients with treatable intellectual disabilities
Biological mechanisms contributing to increased risk of facial clefting
Can laminin-111 be used to treat Duchenne Muscular Dystrophy alone or in combination with myoblast transplantation?
CANADA RESEARCH CHAIRHOLDER/TITULAIRE DES CHAIRES DE RECHERCHE DU CANADA
Cardiolipin synthesis as a therapy for heart failure in persistent pulmonary hypertension
Cardiovascular autonomic control in acute spinal cord injury
Cell biological mechanisms of TDP-43 in amyotrophic lateral sclerosis
Cellular and synaptic mechanisms of TDP-43 proteinopathy using zebrafish.
Characterization of the Pol III-related hypomyelinating leukodystrophies
Chronic childhood vasculitis: Characterizing the individual rare diseases to improve patient outcomes
Comparison of methods to synthesize clinical and economic information for the health technology assessment of novel drugs used in small patient populations with methods used in larger clinical populations and communication of this information to decision makers.
Congenital Heart Block International Research Network (CIRN)
Correction of the dystrophin gene with Zinc Finger Proteins and TAL effector nuclease
Developing a Canadian framework for evaluation and decision-making for expensive drugs for rare diseases through innovation, value, and priority setting
Developing Effective Policies for Managing Technologies for Rare Diseases
Discovering new genes for tetralogy of Fallot and cardiac development
Elucidating the Protective Mechanism of Phospho-N17 Huntingtin in Huntington’s disease
Emerging team in rare diseases: achieving the “triple aim” for inborn errors of metabolism
Emerging Team to identify and characterize novel and existing Hereditary Spastic Paraplegia (HSP) disease genes
Emerging Team: The Scleroderma Patient-centered Intervention Network
Enhanced CARE for RARE Genetic Diseases in Canada
Enzyme Enhancement Therapy for GM1 gangliosidosis
Experimental Therapies to prevent pulmonary hypertension and promote lung vascular growth in congenital diaphragmatic hernia
Français: “Caractérisation d’un nouveau gène important pour le développement du système nerveux entérique.” Anglais: “Characterization of a novel gene required for proper development of the enteric nervous system.”
Functional analysis of non-coding RNA/chromatin interactions at imprinted Prader-Willi Syndrome locus
Functional Dissection of Small RNA Pathways that Impact Chromatin
Genetic Regulation of Myogenesis
Growth arrest and osteoporosis in Duchenne muscular dystrophy patients treated with glucocorticoids
Identification and Characterization of New MicroRNA Biomarkers in Chronic Myeloid Leukemia Stem Cells: Clinical Applications and Pathogenic Significance
Identifying novel roles of calcineurin signaling in the control of multiple complementary pathways affecting the dystrophic phenotype
Improving design and analysis of longitudinal studies of prognosis in uncommon diseases
Improving Muscular Dystrophy Cell Therapy with Drug-Related Gene Knock-Down in Donor Cells
Magnetic resonance imaging biomarkers in ALS
Misfolding of Cu/Zn superoxide dismutase by pathological FUS and TDP43: relevance to amyotrophic lateral sclerosis
Molecular Mechanisms of Ventilator-Induced Diaphragm Dysfunction in Human
Molecular regulation of asymmetric satellite stem cell division
Molecular regulation of progenitor cell behaviour in the developing retina
Molecular regulation of skeletal muscle stem cells
Molecular role of MLIP in myoblast differentiation and regeneration.
Molecular Targeting of Critical Domains of AHI-1 Oncoprotein in Chronic Myeloid Leukemia Stem Cells Resistant to Current Tyrosine Kinase Inhibitor Therapy
Mucopolysaccharidosis I Disease: Tools for Discovery and Design of Chaperone Therapeutics Based on Unique Enzyme Production Systems and the Elucidation of the Structure of alpha-L-Iduronidase
New directions for the use of genetic information by Aboriginal communities: Lessons learned from Québec First Nations with specific monogenic diseases.
New emerging team on Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS): from models to treatment strategies
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
Planning Meeting for Developing a Canadian framework for reimbursement decision-making for expensive drugs for rare diseases
Plasticity and Sensitivity of Renal Cell Carcinoma Cancer Stem Cells
Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy
Prognostic markers and biology of relapsed Hodgkin lymphoma
Regeneration of motor neurons controlling movement and respiration from embryonic stem cells
Regulation of motor neuron identity and circuit development
Roles of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy
Sapropterin for treatment of patients with Phenylketonuria: Identification of subpopulations with substantial clinical benefit
Sepsis-induced skeletal muscle dysfunction: Role of autophagy
SIX family transcription factors in adult muscle regeneration
TDP-43-mediated pathogenic pathways in ALS and new experimental therapeutics
The CHAPTER Study: Congenital Heart Adolescents Participating in Transition Evaluation Research
The FACTs Project: FAbry disease Clinical research and Therapeutics
The ICHANGE (International CHildhood Astrocytomas iNtegrated Genomics and Epigenomics) Consortium
The role of autophagy and posttranslationally myristoylated huntingtin in Huntington disease.
The role of post-translational modifications of MRE11 in mediating the DNA damage response.
The role of the transcriptional co-repressor RIP 140 in muscular dystrophy: a therapeutic target?
The use of Next Generation Exome sequencing in the identification of genes responsible for rare childhood neurologic disorders
Towards Therapeutics For Genetic Corneal Dystrophies
Understanding the pathophysiology of Rasmussen’s encephalitis
2011
A novel investigation of functional pathoanatomy and outcomes of lumbar spinal stenosis 5 years following diagnosis
Abnormal Activation of Thymocytes High-Mobility Group Box Protein (TOX) in Cutaneous T Cell Lymphomas: Pathogenic Significance and Clinical Applications
CD123-Targeted Auger Electron Radioimmunotherapy of Acute Myelogenous Leukemia (AML)
Cellular lipids in Huntington’s disease
Characterization of skeletal muscle inflammation, fibrosis, degeneration and atrophy in response to mycobacterium ulcerans infection
Characterization of the formation of protein aggregates induced by the inhibition of the ubiquitin proteasome system
CIHR Secondary Analysis of Databases: Canadian Pediatric Surgery Network (CAPSNet)
Detection and simulation of femoroacetabular impingement
Development of ganglioside-based therapies for Huntington’s disease
Effects of a Gja1 (gap junction protein alpha1, Connexin 43) gene missense mutation on mesenchymal stem and progenitor cells in a mouse model of human oculodentinodigital dysplasia (ODDD)
Establishing a community-based Long QT resource team: informing the needs of a community at risk
Exploring the functions of the Bub1 and BubR1 kinases during mitosis
Finding of Rare Disease Genes in Canada (FORGE Canada)
Functional characterization of microRNAs in acute myeloid leukemia stem cells
Generation of a humanized mouse xenotransplant model of myelodysplastic syndrome.
Glia-neuron crosstalk in early amyotrophic lateral sclerosis pathogenesis
Identification and characterization of the gene responsible for autosomal dominant spinocerebellar ataxia in the Franco-Ontarian population
Identification of novel genes causing pulmonary fibrosis
Investigation into the cause of Myoclonus Dystonia
Maternal Diabetes and Perinatal Programming: Role of Reactive Oxygen Species
Mechanisms that Regulate Peroxisome Turnover and their role in Neurodegenerative Diseases
Mitochondrial dysfunction and brain energy metabolism in the pathogenesis of Niemann-Pick Type C disease
Molecular Mechanisms of Protein Sorting in the Endocytic Pathway
Multigenic analysis and chemical drug screening using in vivo zebrafish models of motor neurodegenerative disorders
Next-Generation-Sequencing Human Exome pour la découverte de nouveaux gènes impliqués dans les paraplégies spastiques familiales
Novel anti-inflammatory treatment for Amyotrophic Lateral Sclerosis
Nuclear envelopathy in Amyotrophic Lateral Sclerosis-8 (ALS8)
Obstetrical Complications and Long-Term Outcomes of Children Born to Women with Systemic Lupus Erythematosus (SLE)
Pathogenesis and Etiology of Congenital Diaphragmatic Hernia
Physiological functions of the cellular prion protein
Preclinical assessment of clinic ready agents for the treatment of muscular dystrophy and spinal muscular atrophy
Preclinical Assessment of Rho-kinase Inhibitors for Chronic Pulmonary Hypertension
Prion-like intermolecular transmission of superoxide dismutase 1 (SOD1) misfolding in embryonic spinal cord cultures of an amyotrophic lateral sclerosis (ALS) mouse model.
Regulation of type 1 cannabinoid receptor expression in Huntington’s disease.
Role of calcineurin and its signaling modulators in the dystrophic phenotype
Role of endoglin in aberrant TGF-beta signaling in scleroderma
Role of energy balance in age-dependant neurodegeneration and stress response in C.elegans
Role of G-protein-coupled receptor kinase 2 (Gprk2) in Hedgehog signaling
Role of progranulin in the TDP-43/FUS pathway in Amyotrophic Lateral Sclerosis (ALS) pathogenesis
Role of Xin, an actin-binding protein, in satellite cells and muscular dystrophies
Satellite Stem Cells from Skeletal Muscle for the Treatment of Neuromuscular Disease
Specific Targeting of Monomeric SOD1 as a Potential Immunotherapeutic Strategy for ALS.
Strategies for therapy of respiratory muscle failure in muscular dystrophy
Studies on the molecular pathogenesis of Amyotrophic Lateral Sclerosis
Targeting of protein phosphatase 1beta to nuclear actin and myosin.
The function of Wnt signaling via ß-catenin during myogenesis in mouse embryonic stem cells
The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis
Tissue Engineering Therapies for Bone Regeneration in Cleft Palates
Using proteomics to investigate the role of TDP-43 (TAR DNA-binding protein 43) in the pathogenesis of Amyotrophic Lateral Sclerosis
2010
Altered balance of synaptic/extrasynaptic NMDA receptor signaling in Huntington disease
Artificial zinc finger transcription factors targeting the utrophin promoter as a potential therapy for Duchenne muscular dystrophy
Characterization of a novel function for PABPN1: the product of the oculopharyngeal muscular dystrophy disease gene
Characterization of the causative genes and investigation of their role in the development of two new forms of muscular dystrophy in the French-Canadian population.
Chromatin Immunoprecipitation to identify direct targets of MyoD in mouse embryonic stem cells
Development of a novel therapy for treatment of Spinal Muscular Atrophy
Discovering the therapeutic potential of neurotrophin antagonists in Amyotrophic Lateral Sclerosis
Ensuring effective newborn screening: The case of cystic fibrosis
Epithelial-mesenchymal (endothelial)interactions regulate postnatal lung development
Études fonctionnelle des variants d’épissage de FANCA et effets sur la réparation de l’ADN
Exploiting skeletal muscle as a therapeutic target to treat Spinal Muscular Atrophy
Fanconi Anemia signaling and Mus81-Eme1: role in replicative stress and development
Full-Length Huntingtin Protein has a Critical Function in Cell Heat Shock Stress Response that is Affected in Huntington’s Disease.
Functional Architecture of the CFTR Chloride Channel
Genome-wide analysis of bone marrow failure-related genetic alterations in inherited bone marrow failure syndromes
Genome-wide exon capture for targeted resequencing in patients with familial amyotropic lateral sclerosis
Investigation of FMRP-related changes in dendritic morphology and intrinsic properties of ACC pyramidal cells
Involvement of planar cell polarity pathway in glomerular disease
Involvement of planar cell polarity pathway in glomerular disease
Lymph Node Conservation: A Potential New Therapy for the Prevention of Post-Surgical Lymphedema.
MicroRNA (miRNA) modulation of NFL mRNA degradation and translational silencing in ALS
Molecular basis of memory defects in Drosophila Fragile X mutants
Molecular Determinants of Li-Fraumeni Syndrome Associated Cancers
Molecular mechanisms of organelle inheritance
Motor, multisystemic and social participation assessment in myotonic dystrophy type 1: a 9-year longitudinal study
Pathobiology and ribosomal insufficiency in Shwachman-Diamond syndrome
Pathogenesis of striated muscle specific laminopathies: defining the developmental role of LITF in myogenesis and muscle regeneration.
Pathogenic mechanisms associated with neurofilament disorganization
Promoting protection of functionally intact motor units in amyotrophic lateral sclerosis (ALS)
Protein transport into and across cellular membranes
Role and signaling mechanism of EAT-2, an adaptor involved in anti-tumor immunity
Role of the RNA-binding protein Staufen1 in Myotonic Dystrophy type 1
The functional role of a H2AX promoter polymorphism associated with non-Hodgkin lymphoma
The molecular mechanisms of microgliosis in GM2 ganglioside lysosomal storage diseases
The role of TNFalpha in synaptic plasticity and during neurodegeneration
The Terry Fox New Frontiers Program Project in genomics of forme fruste tumours: new vistas on cancer biology and management
Towards Enzyme Enhancement Therapy for Gaucher Disease